Mode of lysozyme protein adsorption at end-tethered polyethylene oxide brushes on gold surfaces determined by neutron reflectivity

Abstract

Abstract: The mode of lysozyme protein adsorption at end-tethered thiol-terminated polyethylene oxide brushes grafted upon gold was determined in situ by neutron reflectivity using the INTER instrument at target station 2, ISIS, RAL, UK. It was found that the most probable position of protein adsorption at these weakly protein resistive brushes was at the gold-brush interface in the so-called primary protein position. Graphical abstract: [Figure not available: see fulltext.]