Chemical composition and antifungal activities of Ziziphora tenuir and Z. clinopodioides essential oils against dermatophytes

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Abstract

Introduction: Ziziphora species are traditionally used for treatment of different infectious and non-infectious diseases as antiseptic agents. Objective: The aim of this study was to evaluate the chemical composition of Ziziphora clinopodioides and Z. tenuir essential oils and their antifungal effects againt five strains of dermatophytes. Methods: GC and GC-MS methods were used for essentional oils analize. The anti-elastase activities were determined by porcine pancreatic elastase assays. Results: 48 different compounds were identified in these two essential oils, which thymol, p-cymene, 1, 8-cineole and γ-terpinene were their major components. The anti-dermatophyte activities of essential oils against dermatophytes showed that the essential oils (150 ppm) inhibited the mycelium growth, about 5-100%, which Z. clinopodioides essential oil had higher mycelium growth inhibition (28-100%) than that of Z. tenuir oil. The MIC and MFC values of essential oils were 0.01-1 μ l/ml. 0.5 μ l/ml essential oils inhibited porcine pancreatic elastase, dose-dependently Conclusions: Due to the anti-dermatophyte and anti-elastase effects of Ziziphora sp., it can be considered as natural antifungal agent for more clinical and pre-clinical trials.

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Mahboubi, M., Tabar, R. H., & Mahdizadeh, E. (2018). Chemical composition and antifungal activities of Ziziphora tenuir and Z. clinopodioides essential oils against dermatophytes. Herba Polonica, 64(2), 37–45. https://doi.org/10.2478/hepo-2018-0011

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