Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral stationary phase. The importance of preparation of representative samples of enantioenriched sulfoxides for chiral HPLC to enable reproducible results is clear.
CITATION STYLE
Flynn, A. J., Ford, A., & Maguire, A. R. (2020). Localized Partitioning of Enantiomers in Solid Samples of Sulfoxides: Importance of Sampling Method in Determination of Enantiopurity. Journal of Organic Chemistry, 85(15), 10216–10221. https://doi.org/10.1021/acs.joc.0c01094
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