Evaluation of portable blood glucose meters for measurement of blood glucose concentration in ferrets (mustela putorius furo)

Abstract

Objective-To evaluate agreement of 3 models of portable blood glucose meters (PBGMs; 2 designed for use with human samples and 1 designed for veterinary use) with a laboratory analyzer for measurement of blood glucose concentrations in ferrets (Mustela putorius furo). Design-Evaluation study. Animals-52 ferrets. Procedures-Samples were analyzed with 4 PBGMs (whole blood) and a laboratory ana- lyzer (plasma). Two PBGMs of the model designed for veterinary use were tested; each was set to a code corresponding to canine or feline sample analysis throughout the study. Agreement and bias between measurements obtained with the PBGMs and the laboratory analyzer were assessed with Bland-Altman plots. Linear regression analysis was performed to evaluate associations with venipuncture site by comparison of central (jugular) and pe- ripheral (lateral saphenous or cephalic) venous blood samples. Results-Plasma glucose concentrations measured with the laboratory analyzer ranged from 41 to 160 mg/dL. Results from the PBGM for veterinary use coded to test a canine blood sample had the greatest agreement with the laboratory analyzer (mean bias, 1. 9 mg/ dL); all other PBGMs significantly underestimated blood glucose concentrations. A PBGM designed for use with human samples had the least agreement with the laboratory analyzer (mean bias, -34.0 mg/dL). Blood glucose concentration was not significantly different be- tween central and peripheral venous blood samples for any analyzer used. Conclusions and Clinical Relevance-Significant underestimation of blood glucose concen- trations as detected for 3 of the 4 PBGMs used in the study could have a substantial impact on clinical decision making. Verification of blood glucose concentrations in ferrets with a labo- ratory analyzer is highly recommended.