Synthesis and Antimicrobial Activity of Newer Quinazolinones

Abstract

2–alkyl–6–bromo–3,1–benzoxazine–4–one (2) is synthesized by treating p –Bromoanthranilic acid and Acetylechoride or Benzoylchloride. Reaction of 2–alkyl–6–bromo–3,1–benzoxazine–4–one (2). with hydrazinehydrate furnish the corresponding 3–Amino–2–methyl–6–bromoquinazoline–4(3 H )–one (3) which on reaction with benzaldehyde afford N,N – arylidene derivative (4). Reaction of 4 with various diazonium salts yields 6–bromo–2–alkyl/aryl–3{[phenyl(phenyldiazenyl)methylene]amino}quinazolin–4(3 H )–one .