Abstract
A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that methylation. IDH-1 mutations were significantly associated with increased overall survival.
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Combs, S. E., Rieken, S., Wick, W., Abdollahi, A., von Deimling, A., Debus, J., & Hartmann, C. (2011). Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back? Radiation Oncology, 6(1). https://doi.org/10.1186/1748-717x-6-115
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