Abstract
In this issue of Cancer Cell, Ott et al. use integrative analysis of histone ChIP-seq and ATAC-seq to describe enhancer-based regulatory circuits in chronic lymphocytic leukemia. This work identified and validated transcription factor PAX5 as main driver of an oncogenic circuitry, which can be disrupted by BET bromodomain inhibition. In this issue of Cancer Cell, Ott et al. use integrative analysis of histone ChIP-seq and ATAC-seq to describe enhancer-based regulatory circuits in chronic lymphocytic leukemia. This work identified and validated transcription factor PAX5 as main driver of an oncogenic circuitry, which can be disrupted by BET bromodomain inhibition.
Cite
CITATION STYLE
Lipka, D. B., Lutsik, P., & Plass, C. (2018, December 10). From Basic Knowledge to Effective Therapies. Cancer Cell. Cell Press. https://doi.org/10.1016/j.ccell.2018.11.013
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