Abstract
Nocardiopsis sp. K-290 was found to produce novel metabolites, designated K-252b, c and d, which were structurally related to K-252a. These compounds were isolated from the culture broth and the physico-chemical and biochemical properties were examined. The compounds strongly inhibited protein kinase C. IC50 values (the concentrations causing 50% inhibition) for the effects of K-252b, c and d on the rat brain enzyme were 38.3, 214, and 337nM, respectively. © 1986, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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CITATION STYLE
Nakanishi, S., Matsuda, Y., Iwahashi, K., & Kase, H. (1986). K-252b, C and D, potent inhibitors of protein kinase C from microbial origin. The Journal of Antibiotics, 39(8), 1066–1071. https://doi.org/10.7164/antibiotics.39.1066
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