Saponin and Sapogenol. XXXVII. Chemical Constituents of Astragali Radix, the Root of Astragalus membranaceus bunge. (4). Astragalosides VII and VIII

Abstract

By means of enzymatic degradation and by application of a selective cleavage method for the glucuronide linkage, as well as by the carbon-13 nuclear magnetic resonance(13C-NMR) analysis, the structures of two astragalosides, which were isolated as two of eleven astragalosides from Astragali Radix (the root of Korean Astragalus membranaceus, Leguminosae), were elucidated: astragaloside VII is 3-O-β-D-xylopyranosyl-6-O-β-D-glucopyranosyl-25-O-β-D-glucopyranosyl-cycloastragenol (4) and astragaloside VIII is 3-O -[α-L-rhamnopyranosyl(1 → 2)-β-D-xylopyranosyl (1→ 2)-β-D-glucuronopyranosyl]soyasapogenl B (8). Astragaloside VII (4) is an unprecedented example of a triterpene-tridesmoside. © 1983, The Pharmaceutical Society of Japan. All rights reserved.