Relation between Anti-Müllerian Hormone with Antral Follicle Count and Ovarian Volume in Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women during reproductive age. Women with PCOS show raised Anti-Mullerian hormone (AMH) levels, due to increased number of small antral follicles and granulosa cells, and these may lead to anovulation. Measuring antral follicle count (AFC) and ovarian volume (OV) by ultrasound scanning gives insight to the ovarian function. This study is conducted to investigate the relation between AMH with AFC, OV and different biochemical parameters which determine PCOS. The study was carried out on thirty patients with PCOS as (group 1) compared with fifteen healthy women as control group (group 2). AMH, FBS, Insulin, HOMA/IR, Testosterone, cholesterol, Triglycerides (TG), body mass index (BMI) and hirsutism were measured for all women in both groups. The results revealed that the serum level of AMH is significantly higher in PCOS (11.90 +/- 4.23ng/ml) than control group (4.36 +/- 0.56ng/ml). As for AFC, there is high significant increase (26.10 +/- 5.49 follicles) in PCOS group versus (9.07 +/- 1.83 follicles) in control group. Furthermore, the results revealed a highly significant difference in OV (11.20 +/- 2.78ml) in PCOS compared to (6.23 +/- 0.73ml) in control. There is a significant correlation between AMH, AFC and OV in PCOS. There is a high significant correlation between AMH, AFC, OV, BMI testosterone, HOMA/IR, HDL, cholesterol, and TG in both groups. It could be concluded that there is a tight positive correlation between AMH and AFC and OV.