Acute I.V. methadone kinetics in man: Relationship to chronic studies

Abstract

Twenty-six patients were given methadone 10mg i v to obtain acute human kinetics. Plasma methadone concentrations from separate 3- and 6-h studies were measured by radioimmunoassay Kinetic parameters derived from triexponential NONLIN analysis showed that T2-Janα and T2-Janβ were 2 and 30 min respectively, no reliable estimate for T2-Janγ could be obtained. The clearance was estimated as 149 ±62 and 163 ± 49 ml min-1 in the 3- and 6-h studies respectively. These values were compared with those published for chronic administration, The difficulties in determining accurate terminal half-life and clearance values from short duration studies are discussed; these difficulties are accentuated by the long terminal half-life of methadone. Appropriate estimates of clearance may be derived from an acute short duration study provided that the average of triexponential fits to individual patient data is used, even when data extend for only 3 h. As might be anticipatedj no analysis produced appropriate terminal half-life values for this drug. © 1982 The Macmillan Press Ltd.