EGFRvIII, a mutated form of EGFR, plays a prominent role in tumorigenesis, but the underlying mechanisms have remained elusive. In this issue of Cancer Cell, Weiss and colleagues implicate phosphorylation of EGFRvIII by EGFR and the consequent phosphorylation of STAT3 as a signaling axis that drives transformation in glioblastoma. © 2013 Elsevier Inc.
Zadeh, G., Bhat, K. P. L., & Aldape, K. (2013, October 14). EGFR and EGFRvIII in Glioblastoma: Partners in Crime. Cancer Cell. https://doi.org/10.1016/j.ccr.2013.09.017