The Effect of Giving Okra (Abelmoschus esculentus L.) Juice on HDL Levels in the Blood Serum of Wistar Strain Rats Fed High-Fat Feed

Abstract

Cardiovascular disease is the biggest cause of death in the world with the number of deaths reaching 17.7 million people (31% of the total number of deaths). The main cause of cardiovascular disease is a disturbance in the function of the heart and blood vessels caused by atherosclerosis due to the deposition of cholesterol in artery walls. High Density Lipoprotein (HDL) functions to transport free cholesterol contained in the endothelial peripheral tissue to HDL receptors located in the liver so that it can be processed to be used as bile. Therapy to increase levels of HDL in the blood using okra juice (Abelmoschus esculentus L.) can be done in rats that have been given high-fat feed. The purpose of this study was to determine the effect of okra juice (Abelmoschus esculentus L.) on HDL levels in rats fed high fat. The study was conducted with giving okra juice (Abelmoschus esculentus L) with dosage difference of 1500 mg/kg bw, 3000 mg/kg bw and 6000 mg/kg bw. The research design used was complete random design with post-test randomized group design with a number of replications 5. Testing of HDL levels was carried out by the CHOD-PAP (Cholesterol Oxidase Para Aminophenazone) method. The research data were analyzed using one-way Anova followed by LSD tests. The results of the study giving okra juice (Abelmoschus esculentus L.) to HDL levels by induction of high-fat feed at a dose of 6000 mg / kg body weight were significantly different from lower dosage. Conclusion, okra juice (Abelmoscus esculentus L.) has a positive effect on increasing HDL levels..