A tertiary care hospital based study on antimicrobial sensitivity pattern among septic patients

Abstract

Introduction: Sepsis is a common and highly fatal clinical syndrome that is characterized by systemic inflammatory response syndrome due to infection. It is a final common pathway of many infectious processes, e.g. bacterial, viral, fungal and parasitic infection in critically ill patients. There is a need of study regarding the sensitivity and resistivity pattern of antimicrobials for the proposal or implementation of rational therapy guidelines. This study will also provide the best microbiological information to clinicians to pick the most effective treatment options, positively influencing patient outcomes. Methodology: A retrospective observational study was conducted among 202 patients at tertiary care teaching hospital during the period from March to November 2018. Patients with sepsis of either gender who are 18 years old or above are included in the study. Non-sepsis adult patient and special populations (pregnant women, psychiatry, HIV) or patients younger than 18 years of age are excluded from the study. Data were collected using validated data collection form. Data were analysed using SPSS 20.0 and Microsoft Excel 2013. Results: From a total of 202 patients involved in the study, the highest incidence rate was found in the age group >68 years. Gram negative organisms isolated were 81.86%, of these Klebsiella species being the most frequent. This isolates showed high rates of sensitivity towards Colistin (96%) Tigecycline (93. 3%). Conclusion: The sensitivity of antibiotics towards species are going down and it is an unpleasant warning of emergence of resistance. From our study it can be anticipated that routine culturing and sensitivity testing should be performed to detect the appearance of resistance.