Kollateralschaden der Cephalosporine und Chinolone und Wege zu Ihrer Reduktion

Abstract

Background: The occurrence of multidrug-resistant microorganisms is associated with an extended and long-term use of broad-spectrum antibiotics. Indeed, this may lead to a colonization and even to an infection of the patient, which is called collateral damage. Moreover, the risk for collateral damage can be assessed for different antibiotic classes. Occurrence of Multidrug-Resistant Microorganisms: The use of cephalosporins may induce a subsequent infection with vancomycin-resistant enterococci, extended-spectrum β-lactamase- producing Klebsiella pneumoniae, β-lactam-resistant Acinetobacter species, and Clostridium difficile. Quinolones are associated with a subsequent infection with methicillin-resistant Staphylococcus aureus and with increasing resistance in gram-negative bacilli, such as Pseudomonas aeruginosa. Conclusion: To avoid the occurrence of multidrug-resistant microorganisms, a strict indication and time-limited use (e.g., 1 week) of antibiotics are required, as already established in the guidelines for infection. © 2009 Urban & Vogel, Muenchen.