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New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity

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A new Ru(II) bipyridyl complex with O4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spec-trometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cyto-toxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were > 300 and 177.63±2.28 μM for the A549 and K562 cells, respectively.




Baroud, A. A., Mihajlović-Lalić, L. E., Stanković, D., Kajzerberger, M., Van Hecke, K., Grgurić-Šipka, S., & Savić, A. (2017). New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. Journal of the Serbian Chemical Society, 82(3), 267–275.

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