Corneal imaging with blue-light optical coherence microscopy

  • Khan S
  • Neuhaus K
  • Thaware O
  • et al.
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Abstract

Corneal imaging is important for the diagnostic and therapeutic evaluation of many eye diseases. Optical coherence tomography (OCT) is extensively used in ocular imaging due to its non-invasive and high-resolution volumetric imaging characteristics. Optical coherence microscopy (OCM) is a technical variation of OCT that can image the cornea with cellular resolution. Here, we demonstrate a blue-light OCM as a low-cost and easily reproducible system to visualize corneal cellular structures such as epithelial cells, endothelial cells, keratocytes, and collagen bundles within stromal lamellae. Our blue-light OCM system achieved an axial resolution of 12 µm in tissue over a 1.2 mm imaging depth, and a lateral resolution of 1.6 µm over a field of view of 750 µm × 750 µm.

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Khan, S., Neuhaus, K., Thaware, O., Ni, S., Ju, M. J., Redd, T., … Jian, Y. (2022). Corneal imaging with blue-light optical coherence microscopy. Biomedical Optics Express, 13(9), 5004. https://doi.org/10.1364/boe.465707

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