2-chlorobenzoylthiourea-modified MCM-41 for drug delivery

Abstract

Mesoporous 2-chlorobenzoylthiourea-modified MCM-41 (2-Cl-BT-MCM-41) was prepared for the first time and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO2) environment. 2-Cl-BT-MCM-41 was prepared and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections observed at low angle XRD show the mesoporous SiO2 structure. The particule size of non-uniform spheres were observed at a range of 250-305 nm. BET surface areas were calculated as 1506 m2/g for MCM-41 and 306 m2/g for 2-Cl-BT-MCM-41, respectively. The absorption and releasing studies of ibuprofen were carried out in simulated body fluid. The result revealed that high adsorption capacity for drug with 2-Cl-BT-MCM-41 and slower drug release rate was achieved.