A Simplified Plasticity Model Based on Synaptic Tagging and Capture Theory: Simplified STC

Abstract

The formation and consolidation of memory play a vital role for survival in an ever-changing environment. In the brain, the change and stabilization of potentiated and depressed synapses are the neural basis of memory formation and maintenance. These changes can be induced by rather short stimuli (only a few seconds or even less) but should then be stable for months or years. Recently, the neural mechanism of conversion from rapid change during the early phase of synaptic plasticity into a stable memory trace in the late phase of synaptic plasticity is more and more clear at the protein and molecular levels, among which synaptic tagging and capture (STC) theory is one of the most popular theories. According to the STC theory, the change and stabilization of synaptic efficiency mainly depend on three processes related to calcium concentration, including synaptic tagging, synthesis of plasticity-related product (PRP), and the capture of PRP by tagged synapse. Based on the STC theory, several computational models are proposed. However, these models hardly take simplicity and biological interpretability into account simultaneously. Here, we propose a simplified STC (SM-STC) model to address this issue. In the SM-STC model, the concentration of calcium ion in each neuronal compartment and synapse is first calculated, and then the tag state of synapse and PRP are updated, and the coupling effect of tagged synapse and PRP is further considered to determine the plasticity state of the synapse, either potentiation or depression. We simulated the Schaffer collaterals pathway of the hippocampus targeting a multicompartment CA1 neuron for several hours of biological time. The results show that the SM-STC model can produce a broad range of experimental phenomena known in the physiological experiments, including long-term potentiation induced by high-frequency stimuli, long-term depression induced by low-frequency stimuli, and cross-capture with two stimuli separated by a delay. Thus, the SM-STC model proposed in this study provides an effective learning rule for brain-like computation on the premise of ensuring biological plausibility and computational efficiency.