Adult low-hypodiploid acute B-lymphoblastic leukemia with IKZF3 deletion and TP53 mutation: Comparison with pediatric patients

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Abstract

Objectives: Chromosomal ploidy is a major risk stratification tool for acute B-cell lymphoblastic leukemia (B-ALL). Low hypodiploidy and near-haploidy are thought to be confined to pediatric B-ALL and associated with a poor prognosis. Doubling of either a low-hypodiploid or a near-haploid clone results in an apparently high-hyperdiploid karyotype, which is often misclassified for risk. Methods: We studied four patients with B-ALL who had chromosome genomic array testing (CGAT), along with fluorescence in situ hybridization and mutation testing. Results: We identified a unique case of adult B-ALL with masked low hypodiploidy (mLH) by genomic duplication, along with a somatic deletion of the IKZF3 gene and a somatic TP53 mutation. Three cases of pediatric B-ALL with mLH, two with TP53 mutations and one untested, were also identified and compared with the adult patient. Conclusions: CGAT was critical in the genotype clarification of these cases through detection of copy-neutral loss of heterozygosity and should be considered performing for B-ALL with apparent hyperdiploidy for accurate prognostic risk stratification and treatment planning.

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APA

Fang, M., Becker, P. S., Linenberger, M., Eaton, K. D., Appelbaum, F. R., Dreyer, Z., … Lu, X. (2015). Adult low-hypodiploid acute B-lymphoblastic leukemia with IKZF3 deletion and TP53 mutation: Comparison with pediatric patients. American Journal of Clinical Pathology, 144(2), 263–270. https://doi.org/10.1309/AJCPW83OXPYKPEEN

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