An efficient synthesis of 4-aryl and 4-vinylphenylalanines by stille cross-coupling reaction

Abstract

The palladium-catalyzed reaction of N-Boc-4-trimethylstannyl-L-phenylalanine methyl ester (1) with a variety of aryl and vinyl iodides and triflates (2) affords the corresponding 4-aryl and 4-vinylphenylalanines 3 in synthetically useful yields.