Antioxidant activity of the exudate from Aloe barbadensis leaves in diabetic rats

Abstract

The effects of the exudate of Aloe barbadensis leaves on oxidative stress and some antioxidant status of streptozotocin induced - diabetic rats were studied. There was significant reduction in scavenging enzymes like superoxide dismutase (SOD) activity and significant increase in signsof oxidative tissue damage, such as lipid peroxidation products (plasma MDA) in streptozotocin induced - diabetic rats. Treatment with Aloe barbadensis (150mg/kg) increased antioxidant enzymes like SOD activities and significantly reduced lipid peroxidation products. This studyshows that high blood sugar leads to increased oxidative stress and that exudates of Aloe barbadensis leaves possessed antioxidant activity as shown by increased scavenging SOD activity and decreases in lipid peroxidation products levels.