Lactate is a high-energy metabolite that is produced in excess when cells lack functional mitochondria and undergo aerobic glycolysis. Lactate can then be transferred to other cells that are underg...
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Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Lin, Z., Ertel, A., Flomenberg, N., Witkiewicz, A. K., … Lisanti, M. P. (2011). Evidence for a stromal-epithelial “lactate shuttle” in human tumors. Cell Cycle, 10(11), 1772–1783. https://doi.org/10.4161/cc.10.11.15659
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