Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older

Abstract

The study goal was to use a very large study cohort to establish normative data for the revised UPSIT (UPSIT-R) and to compare the resultant percentiles to those of the original UPSIT. A second study was performed to compare the performance of these two tests in a cohort of persons with and without Parkinson’s disease (PD). UPSIT-R percentiles were derived by age and sex in 16,972 volunteers. Non-parametric statistics were employed to compare the results of those with and without PD. UPSIT-R performance declined with increasing age; deficits were more pronounced in men than women. The magnitude of the difference between the original and revised test percentile scores differed by age and sex. Olfactory deficits in PD were confirmed on the UPSIT-R. This study provides normative data clinically useful for assessing the relative degree of dysfunction in persons 60 years of age and older using the UPSIT-R. Trial Registration Information: ClinicalTrials.gov NCT05065060.