Proteins take center stage in directing the working of living cells. Every conceivable role within human bodies is played by proteins, from catalysis chemical reactions to defence against alien attack. A variety of quality control mechanisms that operate in the endoplasmic reticulum in downstream compartments of the secretary pathway to ensure the fidelity and regulation of protein expression during cell life and differentiation were introduced. The posttranslational quality control and its relation with protein misfolding were discussed in details. A number of diseases related with protein misfolding were introduced and the principles of therapy were discussed.
CITATION STYLE
Zhou, J. M. (2000). Protein misfolding and disease. Progress in Biochemistry and Biophysics, 27(6), 583–584. https://doi.org/10.1002/9780470048672.wecb647
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