The safety and efficacy of dorsal penile nerve block for premature ejaculation: A systematic review and meta-analysis

Abstract

Background: Premature ejaculation is a common sexual dysfunction disease in adult males. There are many clinical trials shown that dorsal penile nerve block can prolong the ejaculation latency to a certain extent in the vagina. In this study, we aim to use a metaanalysis to evaluate the efficacy and safety of dorsal penile nerve block for premature ejaculation. Methodsandanalysis:We will search for PubMed, Cochrane Library, AMED, EMbase, WorldSciNet, Nature, Science online and China Journal Full-text Database (CNKI), China Biomedical Literature CD-ROM Database (CBM), and related randomized controlled trials included in the China Resources Database. The time is limited from the construction of the library to February 2019. The quality of the included RCTs will be evaluated with the risk of bias (ROB) tool and evidence will be evaluated by GRADE. Data analysis will be used the special software like RevMan (version 5.3) and EndNote X7. Results: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. Ethicsanddissemination: This systematic review will evaluate the efficacy and safety of dorsal penile nerve block for premature ejaculation. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process Trial. Trial registration number PROSPERO CRD42019119691 Abbreviations: AIPE = Arabic index of Premature Ejaculation, CI = confidence interval, CNKI = China National Knowledge Infrastructure, GRADE = grading of recommendations assessment, development and evaluation, IELT = the intravaginal ejaculatory latency time, IPE = index of premature ejaculation, MD = mean difference, NMA = network meta-analysis, PE = premature ejaculation, PEDT = premature ejaculation diagnostic tool, RCT = randomized controlled trial, ROB = risk of bias, SMD = standardized mean difference, VIP = China Science and Technology Journal.