Constituintes químicos do caule de Spathelia excelsa (rutaceae) e atividade frente a Aedes aegypti

Abstract

Recebido em 25/9/08; aceito em 30/4/09; publicado na web em 6/10/09 CHEMICAL CONSTITUENTS OF THE STEMS OF Spathelia excelsa (RUTACEAE) AND ACTIVITY AGAINST Aedes aegypti. Phytochemical investigation from the stems of Spathelia excelsa (Rutaceae) collected in Amazonas yielded deacetylspathelin (1), 7,8-dimethoxyflindersine (2), new glabretal-type triterpenoid 3β-angeloyl-21,24-epoxy-7α,21α,23α,25-tetrahydroxy-4α,4β,8β,10β-tetramethyl-25-dimethyl-14,18-cyclo-5α,13α,14α,17α-cholestane (3), in addition to the known steroids ß-sitosterol and stigmasterol. Their structures were established on the basis of spectral data. The compounds 1 and 3 were assayed on Aedes aegypti (larvicidal and adulticidal activities and compound 3 exhibited larvicidal properties with LC 50 of 4,8 µg/mL.