Synthesis of α-Branched Amines by Three- And Four-Component C–H Functionalization Employing a Readily Diversifiable Hydrazone Directing Group

Abstract

Efficient syntheses of α-branched amines by three- and four-component C–H functionalization employing a diversifiable hydrazone directing group have been developed. The hydrazone in the α-branched amine products has been readily converted to multiple desirable functionalities such as a nitrile, a carboxylic acid, alkenes, and heterocycles using diverse heterolytic chemistry and homolytic transition metal- or photoredox-catalyzed processes. This study represents the first example of a four-component C–H functionalization reaction.