Molecular Docking on Kokosanolide A and C for Anticancer Activity Against Human Breast Cancer Cell MCF-7

Abstract

Kokosanolide A (1), from the seeds of Lansium domesticum Corr. cv Kokossan, has been shown strong cytotoxic activities (IC50 = 8.62 μg/mL) against MCF-7 breast cancer cells. The aim of this work was to study the molecular interactions of kokosanolid A and kokosanolid C with the Estrogen Receptor α (ERα) using computer aided drug design approaches. Molecular docking using Autodock Vina (open-source software PyRx 0.8) was employed to explore the modes of binding of kokosanolid A (1) and kokosanolid C (2) with ERα. Compound 1 and 2 showed strong bond-free energy (-8.8 kcal/mol and-8.7 kcal/mol) to ERα. These two compounds have molecular mechanism to inhibit ERα in breast cancer cells.