Microwave Assisted Synthesis Characterization and Study of Some Novel Chalcones Compounds Derived from Mefenamic Acid

Abstract

New chalcones compounds were synthesis by reaction mefenamyl chloride with P-aminoacetophenone to from N-(4-acetyl phenyl)-2-(2/3-dimethyl phenyl) amino benzamide(A). The chalcones produced by Claisen-Schmidt condensation of compound A with substituted benzaldehydes [(2,4-dihydroxy(1), 3-NH2(2) and 4-OMe (3)] in ethanollic KOH solvent by using microwave irradiation. The new compounds were characterized by M.P, TLC, CHN, FT-IR, 1HNMR and 13CNMR. The biological screening data of the synthesized compounds were also presented. The theoretical study by using AM1 semi-empirical method emphasizes these compounds exists as trans configuration.