A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model

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Abstract

Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion for kidneys. In an autologous canine transplantation model, kidney function and recovery were evaluated after organs were flushed and cold-stored with WMO-II or HTK solution, a perfusate currently approved for clinical use. The average number of red blood cells remaining in a single glomerulus after flushing with WMO-II was significantly reduced when compared with HTK solution. Additionally, WMO-II reduced the number of apoptotic bodies in stored kidneys compared to HTK treated tissue after 48 h of cold storage by reducing expression of Caspase-9, BiP, Chop, and Caspase-12. WMO-II solution reduced serum creatinine levels and serum potassium in kidneys stored for 48 h when compared to HTK perfusion. WMO-II preserves kidney function as evidenced by the reduction in serum creatinine and potassium during graft transplantation.

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APA

Wang, S., Gumpper, K., Tan, T., Luo, X., Guo, H., Ming, C., … Gong, N. (2018, April 10). A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model. Cell and Bioscience. BioMed Central. https://doi.org/10.1186/s13578-018-0226-2

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