Temperature-modulated immunogenicity to Yersinia pestis from Yersinia enterocolitica O3

Abstract

The ability of Yersinia enterocolitica O3, grown at 25°C, to promote cross-immunity to Y. pestis was lost after repeated subcultures at 37°C, which selected for bacterial populations having lower in vivo survival. Subculturing Y. enterocolitica O3 from 37 to 25° C restored the cross-immunogenicity although the in vivo survival remained low.