Chemical constituents of n-butanol extract of Capparis spinosa L.

Abstract

The aim of this study was to ascertain chemical constituents of n-butanol extract of Capparis spinosa L. fruits. The n-butanol extract of Capparis spinosa L. was effective at controlling S180 tumour growth in a murine model. Silica gel column chromatography, Sephadex LH-20 and re-crystallization methods were used to isolate and purify the n-butanol extract. Chemical structures were elucidated by spectroscopic analyses and compared with literature. As results, nine known compounds were isolated and identified as: bis-(5-fomylfurfuryl) ether (1), 5-(hydroxymethyl)furfural (2), uracil (3), adenosine (4), 2-hydroxy-6-methoxy-1H-indol-3-ethanone (5), rutin (6), 2-methyl-6- (1',2',3',4'-tetrahydroxybutyl)pyrazine (7), p-hydroxy-benzoic acid (8) and stachydrine (9). There in, the compound 7 was identified in Capparis spinosa L. for the first time.