Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort during Long-term Follow-up

Abstract

Context: Neurotensin is associated with cardiometabolic diseases but its role with mortality risk in humans is unknown. Objective: This work aims to examine the prediction of proneurotensin (Pro-NT) with respect to total and cause-specific mortality in a middle-aged cohort. Methods: In the population-based middle-aged cohort (n?=?4632; mean age, 57 years) of the Malmö Diet and Cancer Study, Pro-NT was assessed and total as well as cause-specific mortality was studied. Main cause of death was based on the International Classification of Diseases. Results: During a mean follow-up of 20?±?3 years, 950 men and 956 women died. There was significantly increased mortality risk in individuals belonging to the highest quartile (Q) of Pro-NT (Q4, Pro-NT ≥?149 pmol/L) compared with Qs 1 to 3 (Pro-NT