Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines

Abstract

Background/metho:This study evaluated human papillomavirus (HPV) type prevalence in 370 Scottish invasive cervical cancers (ICCs) using HPV genotyping and HPV mRNA detection.Results:HPV 16 and/or 18 was detected in 72% of cancers overall and in 82% of HPV-positive cancers. HPV 45 and 16 were the most frequently transcribed types.Conclusion:A significant reduction in ICC in Scotland should be achieved through the HPV immunisation programme. © 2010 Cancer Research UK All rights reserved.