EVALUATION OF SAFETY AND HAIR GROWTH PROMOTING ACTIVITY OF TRICHUP CAPSULE

Abstract

Hair loss problems can affect physical and mental health of human and have particular relevance during the aging process. In an effort to find solution of such problems, an attempt has been made to evaluate the hair growth promotion activity of a herbo-mineral Ayurvedic formulation, Trichup Tablet. Safety of drug was also evaluated by conducting acute toxicity study as per OECD guideline. For evaluation of hair growth promoting activity selected animals were divided in to three groups where each group was consisting of six animals. TED and TED×2 group was treated with Trichup Tablet at 198 mg/kg/day and 396 mg/kg/day, p.o., for 30 days respectively. Visual parameters, hair length, hair diameter and serum total protein were determined. The animals did not manifest any signs of toxicity or mortality. Treatment of Trichup Tablet showed significant effect on all visual parameters. Length and diameter of hairs were significantly increased in TED and TED×2. Serum total protein was also observed to be elevated in TED and TED×2 in comparison to normal control. On the basis of study data, it can be concluded that Trichup Tablet is safe and having significant hair growth promoting activity. © 2013 are reserved by International Journal of Pharmaceutical Sciences and Research.