Biological evaluation of dihydropyrimidinone synthesized from vanillin, ethylacetoacetate and urea using gooseberry extract

Abstract

The present study focuses on the synthesis, characterization and biological evaluation of dihydropyrimidinone derivative ethyl-4-(4- hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate from vanillin, ethylacetoacetate and urea using gooseberry extract. The synthesised compound is characterized by UV-visible and FT-IR spectroscopy. The synthesised compound shows antibacterial, antifungal, antioxidant and antihelminthic activities. This natural acid catalyzed synthesis is safe, eco-friendly and does not employ any toxic materials and quantifying it as a green approach for the synthesis of organic compounds.