Impaired spatial selectivity and intact phase precession in two-dimensional virtual reality

154Citations
Citations of this article
492Readers
Mendeley users who have this article in their library.
Get full text

Abstract

During real-world (RW) exploration, rodent hippocampal activity shows robust spatial selectivity, which is hypothesized to be governed largely by distal visual cues, although other sensory-motor cues also contribute. Indeed, hippocampal spatial selectivity is weak in primate and human studies that use only visual cues. To determine the contribution of distal visual cues only, we measured hippocampal activity from body-fixed rodents exploring a two-dimensional virtual reality (VR). Compared to that in RW, spatial selectivity was markedly reduced during random foraging and goal-directed tasks in VR. Instead we found small but significant selectivity to distance traveled. Despite impaired spatial selectivity in VR, most spikes occurred within ∼2-s-long hippocampal motifs in both RW and VR that had similar structure, including phase precession within motif fields. Selectivity to space and distance traveled were greatly enhanced in VR tasks with stereotypical trajectories. Thus, distal visual cues alone are insufficient to generate a robust hippocampal rate code for space but are sufficient for a temporal code.

Cite

CITATION STYLE

APA

Aghajan, Z. M., Acharya, L., Moore, J. J., Cushman, J. D., Vuong, C., & Mehta, M. R. (2015). Impaired spatial selectivity and intact phase precession in two-dimensional virtual reality. Nature Neuroscience, 18(1), 121–128. https://doi.org/10.1038/nn.3884

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free