Fluorescent disulfide-functional coordination polymers for sensitive detection of hydrogen peroxide

Abstract

A new type of fluorescent coordination polymer (NCP Cd ) based on disulfide carboxylate ligand was prepared by using one-pot synthesis for sensitive detection of reactive oxygen species (ROS). With the reaction between NCP Cd and ROS, the morphology of the NCP Cd was transformed from nanorods to hexagon particles, then broken into nano-fragments. Meanwhile, the fluorescence of NCP Cd (at 421 nm) was quenched accordingly. For designing the highly sensitive probe for ROS, Rhodamine 6G (R6G) was doped in NCP Cd . In the presence of ROS, the fluorescence of NCP Cd moiety at 421 nm was quenched, but the R6G moiety was released from the broken nanorods and the fluorescence at 555 nm from R6G moiety was recovered. The R6G doped NCP Cd (NCP Cd -R) can be used as a highly sensitive and selective probe for hydrogen peroxide (H 2 O 2 ) with detection limit of 12.4 nM. Moreover, the NCP Cd -R was further extended to the glucose sensing combined with glucose oxidase (GOx) to oxidate glucose and generate H 2 O 2 , demonstrating the potential for practical applications.