Platelet CFH: In search of the source

Abstract

CFH protects platelets against complement attack. In this issue of Blood, Licht and colleagues unexpectedly identify CFH at intracellular localizations other than alpha granules, where CFH had previously been thought to localize. They show accumulation of exogenous CFH in the platelet cytoplasm, as well as production of endogenous CFH by megakaryocytes.