One-pot synthesis of 3,4-dihydropyrimidine-2(1H)-thione derivatives using DBU as green and recyclable catalyst

Abstract

A short and simple one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-thione derivatives was accomplished in excellent yields by reaction of aryl ketone, aryl aldehydes and thiourea in aqueous ethanol (50 %) using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as a reusable catalyst.