Abstract
Background: EAF2 plays an important role in affecting cellular processes, but the mechanisms underlying its effects are poorly understood. Results: EAF2 was identified as a novel repressor of TGF-β signaling through a direct interaction with Smad3. Conclusion: EAF2 specifically interacts with Smad3 to prevent Smad3 nuclear translocation, Smad4-Smad3 complex formation, and p300-Smad3 complex formation. Significance: EAF2 may function by inhibiting TGF-β signaling.
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CITATION STYLE
Liu, X., Chen, Z., Ouyang, G., Song, T., Liang, H., Liu, W., & Xiao, W. (2015). ELL protein-associated factor 2 (EAF2) inhibits transforming growth factor β signaling through a direct interaction with SMAD3. Journal of Biological Chemistry, 290(43), 25933–25945. https://doi.org/10.1074/jbc.M115.663542
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