CYTOTOXIC ACTIVITY OF AVOCADO SEEDS EXTRACTS (PERSEA AMERICANA MILL.) ON T47D CELL LINES

Abstract

Avocado (Persea americana Mill.) is a widely grown plant that had been studied for several activities such as antioxidant and chemopreventive. The aims of this study were to analyze the secondary metabolite compounds contained in avocado seeds and to determine cytotoxic effect from aqueous and ethanolic extracts of avocado seeds against T47D breast cancer cell lines. IC50 value obtained by using MTT assay on aqueous extract, ethanolic extract, and doxorubicin hydrochloride were 560,2 µg/mL, 107,15 µg/mL and 0,26 µg/mL, respectively. Phytochemical screening test had detected the alkaloids, glycosides, phenols, and saponins as chemical groups in avocado seeds extracts.