Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives

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Abstract

Coronavirus disease 2019 (COVID-19) has been a global pandemic, caused by a novel coronavirus strain with strong infectivity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the in-depth research, the close relationship between COVID-19 and immune system has been dug out. During the infection, macrophages, dendritic cells, natural killer cells, CD8+ T cells, Th1, Th17, Tfh cells and effector B cells are all involved in the anti-SARS-CoV-2 responses, however, the dysfunctional immune responses will ultimately lead to the excessive inflammation, acute lung injury, even other organ failure. Thus, a detailed understanding of pertinent immune response during COVID-19 will provide insights in predicting disease outcomes and developing appropriate therapeutic approaches. In this review, we mainly clarify the role of immune cells in COVID-19 and the target-vaccine development and treatment.

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Zhu, Q., Xu, Y., Wang, T., & Xie, F. (2022, November 22). Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2022.1053437

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