A metal-collagen peptide framework for three-dimensional cell culture

Abstract

It won't overstay its welcome: Metal ions trigger the rapid assembly of a triplehelical collagen-based peptide with ligands at the ends and center into a fibrous three-dimensional mesh under physiological conditions (see picture). Importantly for applications in regenerative medicine, a mild chelating agent causes rapid disassembly of the mesh. Human endothelial cells were readily encapsulated and cultured within the collagen-peptide network. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.