Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons

Abstract

Background: The IFN receptor (IFNR) protein level determines cellular responsiveness to IFNs. Results: Knockdown of Jun activation domain-binding protein 1 (JAB1) resulted in the reduction of IFNR level and IFN-induced gene expression. Conclusion: JAB1 stabilizes IFNR and is required for the optimal response to IFNs. Significance: This study provides evidence that JAB1 positively regulates IFN response. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.