Leptosins I and J, cytotoxic substances produced by a leptosphaeria sp. physico-chemical properties and structures

Abstract

Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells. © 1994, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.