Clinical characteristics of ischemic stroke in patients with positive ANCA

Abstract

Objective: To explore the clinical characteristics and recurrence rate of ischemic stroke in patients with antineutrophil cytoplasmic antibody (ANCA), to improve the early diagnosis of these patients, so as to take effective measures to control the progress of the disease and reduce the mortality. Methods: A retrospective analysis of the ischemic stroke patients with ANCA positive and negative status from the neurology department, Baoding No. 1 Central Hospital, Hebei, China. Results: The prevalence of ANCA in 1,297 ischemic stroke patient was 10.10%. The rate of recurrence of ischemic stroke in ANCA positive group was significantly higher than that in ANCA negative group (70.99% vs 35.08%, p < 0.05). The proportion of small-artery occlusion in ANCA positive group was also significantly higher than that in ANCA negative group (33.59% vs 21.96%, p=0.003). The proportion of respiratory tract infection in ANCA positive group (54.96%) was higher than that in ANCA negative group (p < 0.05). The proportion of pulmonary interstitial lesions detected by chest CT in the ANCA positive group was also significantly higher (33.59%) than the ANCA negative group (P < 0.05). Conclusion: ANCA positive etiology accounts for about 10% of ischemic stroke. There is higher rate of recurrent stroke and small artery occlusion.