Eremophilane-type sesquiterpenes from Senecio nemorensis

Abstract

Three new highly oxygenated eremophilane-type sesquiterpenes, 1β,10β(8,12)-diepoxy-7β,11β-dihydroxy-8β, 12α-dimethoxyeremophilane (1), 1β,10β-epoxy-7β-hydroxy- 8α-methoxyeremophil-11αH-12,8β-olide (2), and 6β-isobutyryloxy-8α-hydroxy-1-oxoeremophil-7(11),9-dien-12, 8β-olide (3), together with nine known compounds (4-12) were isolated from the roots and aerial parts of Senecio nemorensis L. (Compositae). Structures of compounds 1-3 were elucidated on the basis of spectroscopic evidence including IR, HR-ESI-MS, 1D and 2D NMR techniques and were unequivocally confirmed by single-crystal X-ray diffraction experiments. The antimicrobial activity of the isolated compounds 1-3 and 8-12 was tested against Staphylococcus aureus and Candida albicans. © Georg Thieme Verlag KG Stuttgart.