Thermosensitive hydrogels: From bench to market

Abstract

Temperature-sensitive hydrogels belong to the class of 'smart hydrogels'. These hydrogels when introduced to an environment of desired temperature have the property to release the drug incorporated in them in a controlled and predictable manner. Hence, they can be used not only as a dosage form but also as a drug delivery system. Thermosensitive hydrogels due to their unique properties have wide applications in the field of biomedical science. This review summarizes various thermosensitive hydrogels that are being used, including natural as well as synthetic polymers-based hydrogels. It is important that the hydrogels have good biocompatibility and biodegradability, as well as their degradation products must be non-toxic and easily excreted out from the body. The technology of nanogels is under development that will help the hydrogels reach areas of the body otherwise difficult to reach. In essence, development of safe and efficient thermosensitive hydrogels that can be marketed and used for various ailments is the key area of research nowadays.